ADAMTS-13 Activity

Alternative Names/Synonyms	ADAMTS13
Laboratory	Core Laboratory & Transfusion Medicine
Sub-section	Hematology
Specimen Type	Blood
Test Code	ADM13

Ordering Instructions, Requisition

MSH Coagulation requisition form (MS 520)

Clinical Significance (If applicable)

ADAMTS13 (a metalloproteinase with thrombospondin type 1 motif 13) is a protease responsible modifying large von Willebrand factor (vWF) and testing for ADAMS13 deficiency is for the diagnosis of thrombotic thrombocytopenic purpura (TTP) and other thrombotic microangiopathies (TMA).

Specimen Requirements (Sample Type)

Plasma (3.2% Na Citrate)

Specimen Requirements (Volume (mL))

Full draw

Specimen Requirements (Tube Type)

Light Blue citrate tube
Collection Containers – Tube Types

Draw (mL)

2.7 mL

Collection Requirements

The 9:1 blood/citrate ratio must be kept constant. Adjustments for the amount of anticoagulant should be made when the hematocrit is abnormal (above 55%). Mix immediately to prevent clotting.
Collection Instructions

Cause for Rejection

Specimen Acceptability and Transport Guidance

Instrument, Methodology

Referred Out: https://stmichaelshospital.com/mirror-hosts/stmichaelshospital.com/programs/labs/tests/

Test Availability

Test may be requested at any time. Samples are aliquotted and frozen. The assay is referred out.

Referral Laboratory

Referred Out to St. Michaels Hospital

Laboratory Contact Information

416-586-4800 Extension 4688

Special Instructions

Must indicate anticoagulant status