Activated Protein C Resistance (APCR) is associated with a point mutation in the Factor V gene (eg Factor V Leiden). This mutation slows the inactivation of factor Va by APC, causing a hypercoagulable state. Factor V Leiden is the most common cause of inherited thrombophilia.
The 9:1 blood/citrate ratio must be kept constant. Adjustments for the amount of anticoagulant should be made when the hematocrit is abnormal (above 55%). Mix immediately to prevent clotting.
Collection Instructions
Send whole blood sample(s) at room temperature as soon as possible.
If specimens cannot be shipped immediately, centrifuge and separate plasma within 1 hour of collection, send frozen plasma on dry ice
Test may be requested at any time. Samples are aliquotted and frozen. The assay is run in batches.
Special arrangements made with Lab
1-4 weeks
APC Resistance: Not detected In case of discrepancies, always interpret results using reference ranges as stated on laboratory reports and/or electronic patient chart.