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Activated Protein C Resistance

Alternative Names/Synonyms	APCR
Laboratory	Core Laboratory & Transfusion Medicine
Sub-section	Hematology
Specimen Type	Blood
Test Code	APCR2

Ordering Instructions, Requisition

MSH Coagulation requisition form (MS 520)

Clinical Significance

Activated Protein C Resistance (APCR) is associated with a point mutation in the Factor V gene (eg Factor V Leiden). This mutation slows the inactivation of factor Va by APC, causing a hypercoagulable state. Factor V Leiden is the most common cause of inherited thrombophilia.

Specimen Requirements (Sample Type)

Plasma (3.2% Na Citrate)

Specimen Requirements (Volume (mL))

Full draw

Specimen Requirements (Tube Type)

Light Blue citrate tube
Collection Containers – Tube Types

Collection Requirements

Blood Collection Instructions

Storage / Shipment Details

Send whole blood sample(s) at room temperature as soon as possible.
If specimens cannot be shipped immediately, centrifuge and separate plasma within 1 hour of collection, send frozen plasma on dry ice

Sample Stability

Fridge: N/A

Room Temperature: 2h,

Freezer: 6 months at -70ºC or below

Cause for Rejection

Specimen Acceptability and Transport Guidance

Instrument, Methodology

Automated Coagulation Analyzer

Test Availability

Test may be requested at any time. Samples are aliquotted and frozen. The assay is run in batches.

STAT Turnaround Time

Special arrangements made with Lab

Routine Turnaround Time

1-4 weeks

Reference Ranges

APC Resistance: Not detected In case of discrepancies, always interpret results using reference ranges as stated on laboratory reports and/or electronic patient chart.

Laboratory Contact Information

416-586-4800 Extension 4688

Special Instructions

Must indicate anticoagulant status