Ashkenazi Jewish Cancer Panel

AJ, AJCP, Germline, Predictive, Hereditary Cancer, HCT, Hereditary Cancer Testing, APC c.3920T>A p.Ile1307Lys, BRCA1 c.68_69del p.Glu23fs, BRCA1 c.5266dupC p.Gln1756Profs, BRCA2 c.5946del p.Ser1982fs, CHEK2 c.1283C>T p.Ser428Phe, GREM1 40 kb dup, MSH2 c.1906G>C p.Ala636Pro, MSH6 c.3984_3987dupGTCA p.Leu1330Valfs, MSH6 c.3959_3962delCAAG p.Ala1320Glufs
Diagnostic Medical Genetics
Advanced Molecular Diagnostics
Blood or DNA
AJC01

Supporting Documents

Peripheral blood or DNA (please specify source if DNA)
2 tubes x 4 mL of blood
5 ug of DNA in TRIS-HCl or water only (no EDTA)
EDTA lavender top for Blood
Collection Containers – Tube Types
or
2 mL screw top tube for DNA
Collect and ship samples at room temperature on the same day. Samples should be received within 24 to 48 hours.
Room Temperature: 7 days
Next Generation Sequencing
STAT, Routine; Monday to Friday
4 weeks
6-8 weeks
molecularlab.MSH@sinaihealth.ca
Yes if not associated with a Genetic Counsellor
APC c.3920T>A p.Ile1307Lys, BRCA1 c.68_69del p.Glu23fs, BRCA1 c.5266dupC p.Gln1756Profs, BRCA2 c.5946del p.Ser1982fs, CHEK2 c.1283C>T p.Ser428Phe, GREM1 40 kb dup, MSH2 c.1906G>C p.Ala636Pro, MSH6 c.3984_3987dupGTCA p.Leu1330Valfs, MSH6 c.3959_3962delCAAG p.Ala1320Glufs
Samples received and processed Monday to Friday 8:30 am - 4:30 pm
Yes
Hereditary Cancer; Indications outlined by Ontario Health (formerly Cancer Care Ontario); see link in Clinical Significance section