Creatinine Clearance

Alternative Names/Synonyms	n/a
Laboratory	Core Laboratory & Transfusion Medicine
Sub-section	Biochemistry
Specimen Type	Refer to Creatinine and Creatinine, 24h Urine
Test Code	Normalized: CCLN2 Not Normalized: CRCUU

Clinical Significance (If applicable)

Assessing renal function through the use of 24h urine and blood measurements of creatinine and body-surface-area (BSA). Creatinine Clearance (CrCl) is calculated via the following equations:

Not Normalized to BSA
Non-normalized CrCl = (Urine creatinine (µmol/L) x Urine volume (L))/(Blood creatinine (µmol/L)) x (1000/86400)

Normalized to BSA
Normalized CrCl = (Non-normalized CrCl) x 1.73/BSA

Specimen Requirements (Sample Type)

Refer to Creatinine and Creatinine, 24h Urine

Specimen Requirements (Volume (mL))

Refer to Creatinine and Creatinine, 24h Urine

Specimen Requirements (Tube Type)

Refer to Creatinine and Creatinine, 24h Urine

Sample Stability

Refer to Creatinine and Creatinine, 24h Urine

Cause for Rejection

Specimen Acceptability and Transport Guidance

Instrument, Methodology

Calculated

Test Availability

24 hours a day, 7 days a week

Routine Turnaround Time

3 hours

Reference Ranges

Not Normalized: 1.3 - 2.0 mL/second
Normalized: See Table

In case of discrepancies, always interpret results using reference ranges as stated on laboratory reports and/or electronic patient chart.

Laboratory Contact Information

416-586-4800 extension 4688