Familial Gastrointestinal Stromal Tumour (7 gene panel)
| HCT, Hereditary Cancer Testing, Germline, Predictive, Hereditary Cancer, KIT, PDGFRA, SDHA, SDHAF2, SDHB, SDHC, SDHD | |
| Diagnostic Medical Genetics | |
| Advanced Molecular Diagnostics | |
| Blood or DNA | |
|
FAGS1
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Supporting Documents
Other Information
Gene panels include both sequencing and deletion/duplication analysis with the exception of GREM1 and EPCAM which are analyzed for large deletions/duplications only. HOXB13 and APC GAPPS variant analysis will be targeted to known pathogenic variants.
Please refer to Genetic Testing Program | Cancer Care Ontario
https://www.cancercareontario.ca/en/guidelines-advice/treatment-modality/pathology-laboratory-testing/genetic-testing-resources
https://www.cancercareontario.ca/en/guidelines-advice/treatment-modality/pathology-laboratory-testing/genetic-testing-resources
Peripheral blood or DNA (please specify source if DNA)
2 tubes x 4 mL of blood
5 ug of DNA in TRIS-HCl or water only (no EDTA)
5 ug of DNA in TRIS-HCl or water only (no EDTA)
Collect and ship samples at room temperature on the same day. Samples should be received within 24 to 48 hours.
Room Temperature: 7 days
Sequencing + CNV
STAT, Routine; Monday to Friday
4 weeks
6-8 weeks
molecularlab.MSH@sinaihealth.ca
Yes if not associated with a Genetic Counsellor
KIT, PDGFRA, SDHA, SDHAF2, SDHB, SDHC, SDHD
Samples received and processed Monday to Friday 8:00 am - 5:00 pm
Yes
Hereditary Cancer; Indications outlined by Ontario Health (formerly Cancer Care Ontario); see link in Clinical Significance section