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HER2 Fluorescence in Situ Hybridization (Breast)
Alternative Names/Synonyms
FISH, HER2 FISH, HER2 ISH
Laboratory
Anatomical Pathology
Sub-section
FISH
Test Code
Group Test: HER2BRF
Ordering Instructions, Requisition
In-house: Reflex test following 2+ HER2 IHC score.
Pathology Consultation and Biomarker Requisition
Supporting Documents
Ontario Health Guidelines
Clinical Significance
Reflex HER2 FISH testing determines HER2 status, guiding targeted therapy and prognosis in breast cancer.
Specimen Requirements (Sample Type)
Formalin fixed paraffin embedded block or tissue sections cut at 4 microns mounted on charged or coated slides.
Collection Requirements
Fixation between 6-72 hours
Storage / Shipment Details
Room temperature (block/unstained slide)
Cause for Rejection
Specimen Acceptability and Transport Guidance
Instrument, Methodology
Dako Omnis
Test Availability
Monday to Friday 8 am - 4 pm
Routine Turnaround Time
Typically 7 days with a maximum of 14 days.
Reference Ranges
Please refer directly to the Pathology Report
Laboratory Contact Information
416-586-4800
Extension 4481 or 3813
Ordering Practices
Reflex testing following a 2+ HER2 IHC score
References
2018 HER2 Testing in Breast Cancer ASCO/CAP Guidelines
https://ascopubs.org/doi/10.1200/JCO.2018.77.8738?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed