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Head & Neck Cancer Panel

Alternative Names/Synonyms	SGT, Somatic Genetic Testing, DEK-AFF2, EWSR1-FLI, EGFR, IDH2, NUTM1, PAX3, PAX7
Laboratory	Diagnostic Medical Genetics
Sub-section	Advanced Molecular Diagnostics
Specimen Type	Fixed Tissue - Formalin Fixed Paraffin Embedded
Test Code	M1HND1, M1HNR1

Ordering Instructions, Requisition

https://www.sinaihealth.ca/media/20281/download?inline

Supporting Documents

Somatic Genetic Testing Reference Sequences

Clinical Significance

Please refer to Genetic Testing Program | Cancer Care Ontario
https://www.cancercareontario.ca/en/guidelines-advice/treatment-modality/pathology-laboratory-testing/genetic-testing-resources

Specimen Requirements (Sample Type)

Formalin Fixed Paraffin Embedded Tissue Block

Specimen Requirements (Volume (mL))

Blocks are preferred.

If submitting slides:
6 x 10um on plain slides + 1 H&E AND 10um curls. Super Clean cutting in 1.5 mL tube

Paraffin Section Cutting Instructions

Storage / Shipment Details

Room Temperature. Must not be refrigerated frozen or exposed to heat.

Cause for Rejection

Specimen Acceptability and Transport Guidance

Test Availability

Routine only; Monday to Friday

Routine Turnaround Time

2 weeks

Laboratory Contact Information

molecularlab.MSH@sinaihealth.ca

Gene(s)

DEK-AFF2, EWSR1-FLI, EGFR, IDH2, NUTM1, PAX3, PAX7

Sample Processing / Delivery

Samples received and processed Monday to Friday 8:00 am - 5:00 pm

Disease/Body Site

Head and Neck; Indications outlined by Ontario Health (formerly Cancer Care Ontario); see link in Clinical Significance section