Hereditary Pheochromocytoma and Paraganglioma (12 gene panel)

HCT, Hereditary Cancer Testing, Germline, Predictive, Hereditary Cancer, FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL
Diagnostic Medical Genetics
Advanced Molecular Genetics
Blood or DNA
HPP1

Supporting Documents

Other Information

Gene panels include both sequencing and deletion/duplication analysis with the exception of GREM1 and EPCAM which are analyzed for large deletions/duplications only. HOXB13 and APC GAPPS variant analysis will be targeted to known pathogenic variants.

Peripheral blood or DNA (please specify source if DNA)

2 tubes x 4 mL for blood
5 ug of DNA in TRIS-HCl or water only (no EDTA)

EDTA lavender top for blood
Collection Containers – Tube Types
or
2 mL screw top tube for DNA

Collect and ship samples at room temperature on the same day. Samples should be received within 24 to 48 hours.

Room Temperature: 7 days

Next Generation Sequencing

STAT, Routine; Monday to Friday

4 weeks

6-8 weeks

molecularlab.MSH@sinaihealth.ca

Yes if not associated with a Genetic Counsellor

FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL

Samples received and processed Monday to Friday 8:30 am - 4:30 pm

Yes

Hereditary Cancer; Indications outlined by Ontario Health (formerly Cancer Care Ontario); see link in Clinical Significance section

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