Lupus Anticoagulants (LACs) occurs in various clinical conditions, especially autoimmune diseases. They are considered to be a risk factor in patients with otherwise unexplained thrombosis and are often present in women who have recurrent fetal loss. They are also associated with a variety of haemostatic problems such as thrombocytopenia and neurological disorders.
The 9:1 blood/citrate ratio must be kept constant. Adjustments for the amount of anticoagulant should be made when the hematocrit is abnormal (above 55%). Mix immediately to prevent clotting.
Collection Instructions
Send whole blood sample(s) at room temperature as soon as possible. If specimens cannot be shipped immediately, centrifuge and separate plasma within 1 hour of collection, send frozen plasma on dry ice