PTT 1:1 Mix
| Mixing studies
APTT Mix |
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| Core Laboratory & Transfusion Medicine | |
| Hematology | |
| Blood | |
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PTTMX
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MSH Coagulation requisition form (MS 520)
The presence of a factor deficiency within the intrinsic and/or common pathway may be detected by performing an APTT assay on a mixture of patient plasma and normal pooled plasma without incubation. If the correction of elevated clotting time is observed, a factor deficiency is most likely present. Failure of the normal plasma to correct the elevated APTT would suggest the presence of an inhibitor.
Plasma (3.2% Na Citrate)
Full draw
Send whole blood sample(s) at room temperature as soon as possible.
If specimens cannot be shipped immediately, centrifuge and separate plasma within 1 hour of collection, send frozen plasma on dry ice
If specimens cannot be shipped immediately, centrifuge and separate plasma within 1 hour of collection, send frozen plasma on dry ice
Fridge: N/A
Room Temperature: 4 hours
Freezer: - 20 °C 2 weeks - 70 °C 12 months
Automated Coagulation Analyzer
24 hours, 7 days/week.
1 hour
2 hours
416-586-4800 Extension 4688
Must indicate anticoagulant status
APTT mixing studies are not performed:
- if the APTT falls within the normal APTT Reference Interval. See Reporting.
- if the patient is on heparin or oral anticoagulant therapy. See Reporting.
- if the APTT falls within the normal APTT Reference Interval. See Reporting.
- if the patient is on heparin or oral anticoagulant therapy. See Reporting.