Screening by IHC, followed by confirmatory fusion testing if a variant is identified.
NTRK testing is incorporated into existing panel testing at diagnosis for the following:
• Non-Small Cell Lung Cancer
• Thyroid cancer
Testing for adult patients with advanced/metastatic solid tumour cancers where NTRK directed therapy is being considered (where surgical resection is likely to result in severe morbidity, and have no satisfactory treatment options) Biomarkers: NTRK1, NTRK2, NTRK3 (Pan-TRK)
Formalin fixed paraffin embedded block or tissue sections cut at 4 microns mounted on "Superfrost Plus" charged slides.