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Sex Hormone Binding Globulin

Alternative Names/Synonyms	Sex Steroid Binding Globulin, Sex Steroid Binding Protein, SHBG, SSBG
Laboratory	Core Laboratory & Transfusion Medicine
Sub-section	Biochemistry
Specimen Type	Blood
Test Code	SSBG2, SBGP2

Clinical Significance

Aiding in the evaluation of disorders related to dysregulation of estrogen, thyroid hormones, and androgens. This includes but is not limited to androgen excess, polycysitic ovarian syndrome, infertility and thyrotoxicosis.

Specimen Requirements (Sample Type)

Serum, Plasma

Specimen Requirements (Volume (mL))

0.5 mL

Specimen Requirements (Tube Type)

Serum (Gold SST)
Plasma (Light Green PST)
Collection Containers – Tube Types

Collection Requirements

Blood Collection Instructions

Sample Stability

Room Temperature: N/A

Fridge: 3 days @ 2-8°C

Freezer: 1 month @ -20°C

Cause for Rejection

Specimen Acceptability and Transport Guidance

Instrument, Methodology

Roche cobas e 602, immunoassay

Test Availability

24 hours a day, 7 days a week

STAT Turnaround Time

1 hour

Routine Turnaround Time

3 hours

Reference Ranges

Pre-Menopausal Females: 26.1 - 110 nmol/L
Post-Menopausal Females: 14.1 - 68.9 nmol/L
Males: 14.5 - 48.4 nmol/L

In case of discrepancies, always interpret results using reference ranges as stated on laboratory reports and/or electronic patient chart.

Laboratory Contact Information

416-586-4800 extension 4688

Ordering Practices

Used in the calculation of Free Androgen Index.