Thyroglobulin Antibodies

Alternative Names/Synonyms	Anti-Tg, aTg
Laboratory	Core Laboratory & Transfusion Medicine
Sub-section	Biochemistry
Specimen Type	Blood
Test Code	ATGS

Clinical Significance

Evaluating thyroglobulin assay interference (false positives) in thyroid cancer patients.

Evaluating Hashimoto's thyroiditis although testing alongside Thyroid Peroxidase Antibodies may be redundant.

Specimen Requirements (Sample Type)

Serum

Specimen Requirements (Volume (mL))

0.5 mL

Specimen Requirements (Tube Type)

Serum (Gold SST)
Collection Containers – Tube Types

Collection Requirements

Blood Collection Instructions

Sample Stability

Room Temperature: N/A

Fridge: 3 days @ 2-8°C

Freezer: 1 month @ -20°C

Cause for Rejection

Specimen Acceptability and Transport Guidance

Instrument, Methodology

Roche cobas e 602, immunoassay

Test Availability

24 hours a day, 7 days a week

STAT Turnaround Time

1 hour

Routine Turnaround Time

3 hours

Reference Ranges

Interference with Thyroglobulin measurement:
Does not interfere: ≤ 22 kIU/L
Does interfere: > 22 kIU/L

Hashimoto’s Thyroiditis:
Negative: ≤ 115 kIU/L
Positive: > 115 kIU/L

In case of discrepancies, always interpret results using reference ranges as stated on laboratory reports and/or electronic patient chart.

Laboratory Contact Information

416-586-4800 extension 4688